{"id":2896,"date":"2018-02-16T16:41:07","date_gmt":"2018-02-16T16:41:07","guid":{"rendered":"http:\/\/www.sarmsthailand.com\/?p=2896"},"modified":"2026-07-26T15:43:45","modified_gmt":"2026-07-26T15:43:45","slug":"mk-677-nutrobal","status":"publish","type":"post","link":"https:\/\/www.sarmsthailand.com\/th\/sarms-guides\/mk-677-nutrobal\/","title":{"rendered":"MK-677 Ibutamoren Guide: Research, Uses and Cycle Information"},"content":{"rendered":"<div style=\"max-width:960px;margin:0 auto;color:#374151;line-height:1.75;\">\n<p>MK-677, Ibutamoren and MK-0677 are names used for the same investigational growth-hormone secretagogue. It is commonly grouped with SARMs in the performance market, but it does not act through the androgen receptor and is not technically a selective androgen receptor modulator.<\/p>\n<div style=\"margin:26px 0;padding:24px;background:#f8faf9;border:1px solid #dfe7e2;border-radius:9px;\">\n<h2 style=\"margin-top:0;\">MK-677 Ibutamoren at a Glance<\/h2>\n<ul>\n<li><strong>Common name:<\/strong> Ibutamoren<\/li>\n<li><strong>Development codes:<\/strong> MK-677 and MK-0677<\/li>\n<li><strong>Other research names:<\/strong> L-163,191 and LUM-201<\/li>\n<li><strong>Compound class:<\/strong> Growth-hormone secretagogue and ghrelin-receptor agonist<\/li>\n<li><strong>Is it a SARM?<\/strong> No<\/li>\n<li><strong>Format sold by Sarms Thailand:<\/strong> 20 mg\/ml liquid in a 30ml bottle<\/li>\n<li><strong>Research areas:<\/strong> Growth hormone, IGF-1, body composition, nitrogen balance and sleep<\/li>\n<\/ul>\n<p style=\"margin-bottom:0;\"><a href=\"\/th\/product\/nutrobal\/\" style=\"display:inline-block;padding:12px 20px;background:#176b51;color:#ffffff;text-decoration:none;border-radius:5px;font-weight:700;\">View MK-677 Ibutamoren Product<\/a><\/p>\n<\/div>\n<h2>What Is MK-677 Ibutamoren?<\/h2>\n<p>MK-677 is an orally active, non-peptide growth-hormone secretagogue. It was developed to stimulate the body\u2019s own growth-hormone signalling without requiring an injected peptide or growth-hormone product.<\/p>\n<p>Ibutamoren, MK-677 and MK-0677 refer to the same compound. LUM-201 is a later development name used in clinical research involving growth-hormone deficiency.<\/p>\n<p>MK-677 remains investigational. It is not approved as a general muscle-building, recovery, anti-ageing or athletic-performance medicine.<\/p>\n<h2>Is MK-677 a SARM?<\/h2>\n<p>No. MK-677 does not belong to the selective androgen receptor modulator class.<\/p>\n<p>True SARMs such as Ostarine, LGD-4033 and RAD-140 bind to androgen receptors. MK-677 instead activates the growth-hormone secretagogue receptor, also known as the ghrelin receptor.<\/p>\n<p>It is commonly sold alongside SARMs because it appears in the same performance-focused market and is sometimes included in SARM stacks. That commercial grouping does not change its compound classification.<\/p>\n<h2>How Does MK-677 Work?<\/h2>\n<p>MK-677 acts as an agonist of the ghrelin receptor. Ghrelin-receptor activation can stimulate the pituitary gland to release growth hormone.<\/p>\n<p>This can increase pulsatile growth-hormone secretion and raise insulin-like growth factor 1, commonly abbreviated as IGF-1. MK-677 stimulates endogenous signalling rather than supplying injected growth hormone directly.<\/p>\n<p>Because the ghrelin receptor is also involved in appetite and metabolic regulation, MK-677 research has examined more than growth-hormone levels alone.<\/p>\n<h2>Human Research on Growth Hormone and IGF-1<\/h2>\n<p>Several controlled human studies have shown that MK-677 can increase growth-hormone secretion and IGF-1 concentrations.<\/p>\n<p>A seven-day study in healthy young men found that oral MK-677 increased growth-hormone pulse amplitude and IGF-1. Earlier research in older adults also reported sustained stimulation of the growth-hormone and IGF-1 axis during daily administration.<\/p>\n<p>These findings establish that MK-677 has measurable activity in humans. They do not establish a guaranteed change in muscle size, strength, recovery or physical appearance.<\/p>\n<h2>MK-677 and Fat-Free Mass<\/h2>\n<p>A randomized study followed healthy adults aged 60 to 81 who received MK-677 or placebo for approximately one year. The researchers reported that MK-677 increased pulsatile growth-hormone secretion and significantly increased fat-free mass.<\/p>\n<p>The study did not report a significant reduction in total fat mass or abdominal visceral fat. Strength and functional outcomes also did not improve significantly.<\/p>\n<p>Fat-free mass includes more than contractile muscle tissue. Changes in intracellular water, connective tissue and other lean components can contribute to the measurement, so an increase in fat-free mass should not automatically be described as an equivalent increase in visible muscle.<\/p>\n<h2>MK-677 During Calorie Restriction<\/h2>\n<p>A controlled crossover study evaluated MK-677 in eight healthy men during short-term calorie restriction. The researchers examined whether the compound could affect the negative nitrogen balance produced by restricted calorie intake.<\/p>\n<p>MK-677 increased growth hormone and IGF-1 and reversed the measured diet-induced nitrogen loss during the treatment period.<\/p>\n<p>This study contributed to interest in MK-677 for preserving lean tissue during calorie restriction. However, it was a small and short clinical experiment, not a bodybuilding cutting trial.<\/p>\n<h2>MK-677 and Body Fat<\/h2>\n<p>MK-677 should not be described as a direct fat-burning compound. Controlled studies have generally focused on growth hormone, IGF-1, nitrogen balance and fat-free mass rather than demonstrating reliable fat loss.<\/p>\n<p>In the twelve-month older-adult study, total fat mass and abdominal visceral fat did not decrease significantly. Changes in body fat remain strongly influenced by calorie intake, nutrition, activity and training.<\/p>\n<h2>MK-677 and Sleep Research<\/h2>\n<p>Small controlled studies have investigated the effect of MK-677 on sleep architecture in younger and older adults.<\/p>\n<p>Researchers reported changes in rapid-eye-movement sleep and slow-wave sleep during treatment. These findings contributed to performance-market discussions about sleep and recovery.<\/p>\n<p>The studies were small and should not be used to guarantee better sleep for every user or to present MK-677 as an established treatment for insomnia or other sleep disorders.<\/p>\n<h2>Appetite and the Ghrelin Receptor<\/h2>\n<p>Ghrelin is closely involved in appetite signalling, which helps explain why increased appetite is frequently associated with MK-677 discussions.<\/p>\n<p>Appetite response can vary. Increased food intake may work against a calorie-controlled cutting plan even when a compound is being researched for growth-hormone or body-composition effects.<\/p>\n<p>MK-677 should therefore not automatically be categorized as a cutting product simply because it is sold alongside SARMs.<\/p>\n<h2>Blood Glucose and Insulin Sensitivity<\/h2>\n<p>Growth-hormone signalling can influence glucose metabolism. In the twelve-month study of older adults, fasting glucose increased modestly and insulin sensitivity declined during MK-677 treatment.<\/p>\n<p>Other controlled research has also reported changes in glucose tolerance or insulin measurements. These findings are relevant when reviewing MK-677 and should not be omitted from its research profile.<\/p>\n<p>Someone with existing glucose-control concerns requires appropriate medical evaluation rather than relying on general bodybuilding information.<\/p>\n<h2>Common MK-677 Cycle Discussions<\/h2>\n<p>Performance communities commonly discuss MK-677 use over longer periods than many traditional SARM cycles because it does not work through the androgen receptor.<\/p>\n<p>Daily amounts commonly discussed online are often in the 10\u201325 mg range. These are non-medical community patterns rather than clinically approved bodybuilding protocols.<\/p>\n<p>Human studies have used different amounts and durations depending on the population and research objective. Results from elderly adults, calorie-restricted volunteers or growth-hormone-deficient participants cannot automatically be transferred to healthy recreational users.<\/p>\n<div style=\"margin:22px 0;padding:18px 20px;background:#f3f4f6;border-radius:7px;\">\n<h3 style=\"margin-top:0;\">Understanding a 20 mg\/ml Liquid Concentration<\/h3>\n<p>For a liquid containing 20 mg per ml:<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>1 ml contains 20 mg<\/li>\n<li>0.5 ml contains 10 mg<\/li>\n<li>0.25 ml contains 5 mg<\/li>\n<\/ul>\n<p style=\"margin:14px 0 0;\"><small>This is concentration math only and is not a personalized dosage recommendation.<\/small><\/p>\n<\/div>\n<h2>Does MK-677 Require PCT?<\/h2>\n<p>MK-677 is not an androgen receptor modulator and is not typically associated with testosterone suppression through the same mechanism as SARMs such as LGD-4033 or RAD-140.<\/p>\n<p>For that reason, MK-677 used by itself is not generally the compound driving SARM PCT discussions. However, it is frequently combined with suppressive SARMs in performance-market stacks.<\/p>\n<p>When MK-677 is used alongside a SARM, post-cycle considerations relate primarily to the androgen-receptor compounds included in the cycle. Those compounds should be evaluated individually rather than treating the entire stack as one product.<\/p>\n<p>Available post-cycle products can be compared in the <a href=\"\/th\/product-category\/sarms-pct-estrogen-blockers\/\">SARM PCT and Post-Cycle Support<\/a> category.<\/p>\n<h2>MK-677 Compared With Ostarine<\/h2>\n<p>MK-677 and Ostarine are not members of the same compound class.<\/p>\n<p><a href=\"\/th\/sarms-guides\/mk-2866-ostarine\/\">Ostarine MK-2866<\/a> is a selective androgen receptor modulator researched for lean body mass and physical function. MK-677 is a growth-hormone secretagogue researched for its effects on growth-hormone and IGF-1 signalling.<\/p>\n<p>The Sarms Thailand Ostarine product contains 25 mg per ml, while MK-677 contains 20 mg per ml. Concentration does not provide a valid direct comparison because the compounds work through different biological pathways.<\/p>\n<h2>MK-677 Compared With LGD-4033<\/h2>\n<p><a href=\"\/th\/sarms-guides\/lgd-4033-ligandrol\/\">LGD-4033 Ligandrol<\/a> binds to the androgen receptor and has produced measurable hormonal suppression in controlled human research.<\/p>\n<p>MK-677 activates the ghrelin receptor and does not have the same androgen-receptor mechanism. Its important research considerations instead include growth-hormone, IGF-1, appetite and glucose metabolism.<\/p>\n<p>They should therefore not be presented as interchangeable alternatives.<\/p>\n<h2>MK-677 in SARM Stacks<\/h2>\n<p>MK-677 appears in several pre-built packages alongside products such as RAD-140, LGD-4033, S-4 and Cardarine.<\/p>\n<p>Only some of those compounds are true SARMs. Cardarine is a PPAR-delta agonist, while MK-677 is a growth-hormone secretagogue.<\/p>\n<p>Combining several compounds creates a more complex cycle than using one product alone. Each ingredient has a separate mechanism, evidence base and monitoring consideration.<\/p>\n<p>Current combinations can be reviewed in the <a href=\"\/th\/product-category\/sarms-stacks\/\">SARM Stacks in Thailand<\/a> category.<\/p>\n<h2>MK-677 Research Status<\/h2>\n<p>MK-677 remains an investigational compound. It has been administered in controlled human studies, but it is not approved as a general bodybuilding, muscle-building, recovery or athletic-performance medicine.<\/p>\n<p>The compound remains under clinical investigation in selected medical research programs under development names including LUM-201.<\/p>\n<p>Ibutamoren MK-677 is listed by the World Anti-Doping Agency among prohibited growth-hormone secretagogues. Athletes subject to drug testing should avoid products containing MK-677, MK-0677 or Ibutamoren.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<h3>Are MK-677, Ibutamoren and MK-0677 the same compound?<\/h3>\n<p>Yes. Ibutamoren is the common compound name, while MK-677 and MK-0677 are development codes associated with the same substance.<\/p>\n<h3>Is MK-677 a real SARM?<\/h3>\n<p>No. MK-677 is a growth-hormone secretagogue and ghrelin-receptor agonist. It does not belong to the selective androgen receptor modulator class.<\/p>\n<h3>Does MK-677 increase growth hormone?<\/h3>\n<p>Controlled human studies have reported increased pulsatile growth-hormone secretion and higher IGF-1 concentrations during MK-677 treatment.<\/p>\n<h3>Did MK-677 increase muscle in human studies?<\/h3>\n<p>A twelve-month study reported increased fat-free mass, but it did not show significant improvements in strength or physical function. Fat-free mass should not be interpreted as an exact measurement of newly developed muscle tissue.<\/p>\n<h3>Does MK-677 burn fat?<\/h3>\n<p>Controlled research has not established MK-677 as a direct fat-loss compound. Total and abdominal fat did not decrease significantly in the twelve-month older-adult study.<\/p>\n<h3>How much MK-677 is in 1 ml?<\/h3>\n<p>In a liquid containing 20 mg per ml, one full millilitre contains 20 mg of MK-677.<\/p>\n<h3>Does MK-677 require SARM PCT?<\/h3>\n<p>MK-677 does not act through the androgen receptor and is not generally the compound responsible for SARM-related suppression. When it is combined with genuine SARMs, post-cycle considerations relate mainly to those androgen-receptor compounds.<\/p>\n<h2>MK-677 Research Sources<\/h2>\n<ul>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2757071\/\" target=\"_blank\" rel=\"noopener noreferrer\">Twelve-month randomized MK-677 study in healthy older adults<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9467534\/\" target=\"_blank\" rel=\"noopener noreferrer\">MK-677 study during calorie restriction and nitrogen loss<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9349662\/\" target=\"_blank\" rel=\"noopener noreferrer\">Controlled MK-677 sleep research<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9467542\/\" target=\"_blank\" rel=\"noopener noreferrer\">Two-month MK-677 study in obese men<\/a><\/li>\n<li><a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Ibutamoren\" target=\"_blank\" rel=\"noopener noreferrer\">PubChem information for Ibutamoren<\/a><\/li>\n<li><a href=\"https:\/\/www.wada-ama.org\/en\/prohibited-list\" target=\"_blank\" rel=\"noopener noreferrer\">World Anti-Doping Agency Prohibited List<\/a><\/li>\n<\/ul>\n<div style=\"margin-top:28px;padding:20px;background:#fff8e8;border-left:4px solid #d5a72d;border-radius:6px;\">\n<p style=\"margin:0;\"><strong>Editorial and commercial disclosure:<\/strong> Sarms Thailand sells an MK-677 Ibutamoren product. This guide separates controlled human research from commonly discussed non-medical cycle information. Community use patterns are not presented as clinically validated protocols.<\/p>\n<\/div>\n<div style=\"margin-top:28px;padding:24px;background:#f8faf9;border:1px solid #dfe7e2;border-radius:9px;text-align:center;\">\n<h2 style=\"margin-top:0;\">View MK-677 Ibutamoren in Thailand<\/h2>\n<p>Review the current 20 mg\/ml concentration, 30ml bottle size, availability and supporting product information.<\/p>\n<p style=\"margin-bottom:0;\"><a href=\"\/th\/product\/nutrobal\/\" style=\"display:inline-block;padding:12px 22px;background:#176b51;color:#ffffff;text-decoration:none;border-radius:5px;font-weight:700;\">View MK-677 Product<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>MK-677, Ibutamoren and MK-0677 are names used for the same investigational growth-hormone secretagogue. It is commonly grouped with SARMs in the performance market, but it does not act through the androgen receptor and is not technically a selective androgen receptor modulator. MK-677 Ibutamoren at a Glance Common name: Ibutamoren Development codes: MK-677 and MK-0677 Other [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3639,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2896","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sarms-guides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MK-677 Ibutamoren Guide | Research &amp; Cycle Information<\/title>\n<meta name=\"description\" content=\"MK-677 Ibutamoren guide covering growth hormone and IGF-1 research, fat-free mass, sleep, glucose findings, liquid concentration and cycle discussions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sarmsthailand.com\/th\/sarms-guides\/mk-677-nutrobal\/\" 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